Fresh analysis suggests that people who stop using popular weight-loss injections like semaglutide or tirzepatide can put back on lost weight far faster than those who stop traditional diet and exercise programs.
Published data in a major health publication demonstrates that while obese people frequently drop about a fifth of their body weight while on the medication, the weight comes back at an estimated rate of nearly a kilo each month after stopping.
"Users purchasing these treatments need to be aware of the danger of quick weight regain when the medication ends," cautioned researcher Dr. Susan Jebb.
That rate of regain means a return to original mass in about 18 months.
Comparing Therapies
The research, which looked at 37 of studies involving over 9,000 of patients, compared the results of these new drugs with older methods.
The team note that people who lose weight through dieting usually have a slower weight regain—perhaps 100 grams monthly—post-intervention.
The Reason for the Fast Rebound
Nutrition scientists propose the mode of action of the injections is key to understanding the accelerated regain.
These medications copy a natural hormone called GLP-1, which controls appetite.
"Artificially providing GLP-1 levels far above than normal may cause the system to produce less of its own natural GLP-1, and could diminish responsiveness to its effects," explained Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication leads to hunger is no longer kept in check, making excessive eating much more probable."
A Chronic Condition?
The NHS suggest the injections for individuals with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts argue that, considering the likelihood of relapse, the treatment is often life-long.
This perspective is reinforced by pharmaceutical companies, who note that the results "underscore the chronic nature of obesity," akin to managing conditions like hypertension.
User Accounts
People who have come off the jabs describe a sudden return of cravings.
"It was like a switch that goes on and you're instantly extremely hungry," said an individual.
This challenge is worsened if individuals have not established sustainable lifestyle or habit modifications during treatment.
Significant Adoption
Survey data indicate that millions of people in the UK have tried weight-loss jabs in the past year, with demand being substantial.
- Use is higher among women compared to males.
- The middle-aged age group shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than public health services.
Ultimately, researchers emphasize that while GLP-1 drugs are potent agents for shedding pounds, they are not a magic solution and lasting health benefits likely depends on integrated behavioural support.
